BINDING AGENT FOR BIOACTIVE PREPARATIONS, METHOD OF ITS SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS Russian patent published in 1998 - IPC

FIELD: medicine, oncology, pharmacy. SUBSTANCE: binding agent: conjugate of the general formula: [A-O-W-Z]_a-T where T - carrier fragment; A-O-W is a residue of therapeutically acceptable anthracycline; Z - spacer group. Conjugate is synthesized by condensation of compound of the formula A-O-W-OH or its activated derivative with a substance (or their mixture) that is a spacer group Z, and with carrier fragment T. Condensation can be carried out in the presence of condensing agent. T - T-cellular antibodies, antibodies raised against CD5, transferrin receptors and others. Invention claims the compound of the formula A-O-W-[piperazine]-H that can be used for conjugate preparing. Invention can be used for treatment of some tumors in mammalian. EFFECT: improved therapeutic effect of drugs, decreased toxic effect after administration into body. 13 cl, 4 tbl