FIELD: biotechnology.
SUBSTANCE: following are presented: a constructed multispecific antibody and an isolated antibody, a multimeric protein with asymmetric mutations in the CH2–CH3 region, and methods of their preparation. Also the following is proposed: pharmaceutical compositions for the treatment of oncological diseases, an isolated polynucleotide encoding a multispecific antibody, an expression vector and a host cell producing a multispecific antibody.
EFFECT: group of inventions makes it possible to obtain antibodies with a reduced ability to bind protein A and use them for the treatment of oncological diseases.
56 cl, 25 dwg, 16 tbl, 7 ex
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