FIELD: biotechnology.
SUBSTANCE: bispecific antibody that binds two different epitopes, a pharmaceutical composition for treating a tumor associated with the first epitope and a second epitope, including the above bispecific antibody, a conjugate that binds the first epitope and the second epitope, a fusion protein that binds the first epitope and the second epitope, a polynucleotide encoding a bispecific antibody, a cell expressing a bispecific antibody, the use of a bispecific antibody or conjugate or fusion protein for the treatment of a tumor associated with a first and second epitope, and the use of a bispecific antibody or conjugate or fusion protein for the preparation of a reagent or kit for detecting a tumor associated with the first epitope and the second epitope.
EFFECT: expanding the scope of agents that bind two different epitopes.
31 cl, 36 dwg, 35 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MOLECULES TARGETING A TYPE III SECRETION SYSTEM | 2016 |
|
RU2759949C2 |
| MULTIVALENT AND MULTISPECIFIC HYBRID PROTEINS THAT BIND TO DR5 | 2016 |
|
RU2748620C2 |
| POLYPEPTIDE LINKER FOR PRODUCTION OF MULTI-SPECIFIC ANTIBODIES | 2018 |
|
RU2776302C2 |
| HYBRID PROTEINS OF sPD-1-Fc VARIANT | 2019 |
|
RU2785993C2 |
| POLYFUNCTIONAL PROTEIN MOLECULES CONTAINING DECORIN AND USE THEREOF | 2019 |
|
RU2823357C2 |
| IMMUNOCYTOKINES AND THEIR USE | 2021 |
|
RU2818371C1 |
| ANTIBODIES CONTAINING POLYPEPTIDE INTEGRATED INTO FRAME REGION 3 | 2019 |
|
RU2796254C2 |
| MONOVALENT ANTIBODIES TO PROPERDIN AND FRAGMENTS OF ANTIBODIES | 2018 |
|
RU2790103C2 |
| NEW MODIFIED IMMUNOGLOBULIN Fc-FRAGMENT FUNCTION PROTEIN AND ITS USE | 2020 |
|
RU2800919C2 |
| AMATOXIN ANTIBODY-DRUG CONJUGATES AND USE THEREOF | 2020 |
|
RU2826004C2 |
