FIELD: organic chemistry.
SUBSTANCE: method for obtaining N-substituted bridging 1,2,4-dioxazolidines of the general formula
where R1=H, lower alkyl, C6H5CH2, 4-FC6H4CH2, 4-BrC6H4CH2, 4-ClC6H4CH2, CH2CH=CH2, (CH2)2C(O)OEt, R2=H, C(O)OEt, C(O)OCH2CH=CH2, C(O)OBut, C(O)CH2C6H5, R3=H, 4-NO2C6H4, R4=o-BrC6H5, CH2CN, 1-adamantyl, 2-pyrazyl, n-CH3C6H4, 2-furyl, 2-thiophenyl, NH2, X=C(O), SO2, which consists in the fact that 1,5-diketones of the general formula
where R1, R2 and R3 have the above meanings, are reacted with an aqueous solution of hydrogen peroxide and a hydrazide of the general formula NH2NHXR4, where X and R4 have the above meanings, in methanol in the presence of an acid catalyst.
EFFECT: obtaining compounds containing in their structure a cyclic peroxide fragment and an N-substituted amino group, of general formula I in high yield, which can be used in medicine as antimalarial and anticancer agents.
3 cl, 36 ex
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Authors
Dates
2023-09-28—Published
2023-02-20—Filed