METHOD OF PRODUCING TWO 4-{[(2S)-2-{4-[5-CHLORO-2-(1H-1,2,3-TRIAZOL-1-YL)PHENYL]-5-METHOXY-2-OXOPYRIDIN-1(2H)-IL} BUTANOYL]AMINO}-2-FLUOROBENZAMIDE DERIVATIVES Russian patent published in 2023 - IPC C07D401/10 C07C233/64 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a method of obtaining 4-({(2S)-2-[4-{5-chloro-2-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}-5 -methoxy-2-oxopyridin-1(2H)-yl]butanoyl}-amino)-2-fluorobenzamide (II), the said method includes adding 4-{5-chloro-2-[4-(trifluoromethyl)-1H -1,2,3-triazol-1-yl]phenyl}-5-methoxypyridin-2(1H)-one (XVI-CF3) to react with 4-{[(2R)-2-bromobutanoyl]amino}- 2-fluorobenzamide (XIX) in the presence of a base in a solvent, followed by isolation of the compound of formula (II). The invention also relates to intermediate compounds of formulas (XV-CF₃), (XVI-CF3), (XIX) used in the said method.

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EFFECT: development of a new method of obtaining 4-({(2S)-2-[4-{5-chloro-2-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}-5-methoxy-2-oxopyridin-1(2H)-yl]butanoyl}-amino)-2-fluorobenzamide with high yield.

13 cl, 9 dwg