FIELD: biotechnology.
SUBSTANCE: invention relates to chimeric antigen receptors specific for mucin-1, and can be used in medicine for the treatment of cancer. Designs of polypeptides that bind to mucin-1 and include a pair of variable heavy chain region (VH) and variable region light chain (VL) with certain combinations of CDRs have been proposed. The proposed polypeptides can be produced recombinantly and can be incorporated into a chimeric antigen receptor expressed on an immune cell for the treatment of cancer.
EFFECT: invention makes it possible to continuously provide a strong antitumor effect on various types of cancer due to the activation of the immune system in the body.
25 cl, 19 dwg, 6 tbl, 16 ex
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