BENZOTHIOPHENES AND RELATED COMPOUNDS AS STING AGONISTS Russian patent published in 2023 - IPC C07D277/64 C07D333/56 C07D409/12 C07D417/12 C07D495/04 C07D498/04 A61K31/381 A61K31/4365 A61P35/00 

Abstract RU 2806274 C2

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to compounds of general formula (I), general formula (II), general formula (III), general formula (IV), general formula (V), general formula (VI) and their pharmaceutically acceptable salts, where all the variables are defined in herein, which may be useful as inducers of type I interferon production, specifically as active agents of STING. Also the following is provided: a pharmaceutical composition containing such compounds and methods of using such compounds, including administering such compounds to induce an immune response, induce STING-dependent type I interferon production, and/or treat a cell proliferation disorder such as cancer.

EFFECT: obtaining sting agonists compounds.

33 cl, 26 tbl, 190 ex

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RU 2 806 274 C2

Authors

Altman, Majkl, D.

Kesh, Brendon, D.

Childers, Mettyu Llojd

Kamming, Dzhared, N.

Demong, Duejn, E.

Khejdl, Endryu Mark

Khenderson, Timoti, Dzh.

Dzhuvell, Dzhejms, P.

Larsen, Mettyu, A.

Lim, Dzhongvon

Lu, Min

Otte, Rajan, D.

Trotter, Bendzhamin Uesli

Dates

2023-10-30Published

2019-04-01Filed