POLYVALENT IMMUNOGENIC COMPOSITION AGAINST HUMAN PAPILLOMAVIRUS Russian patent published in 2023 - IPC C07K14/25 C12N15/37 A61K39/12 A61P35/00 A61P31/20 A61P15/00 

FIELD: biotechnology.

SUBSTANCE: following is described: a multivalent immunogenic composition of human papillomavirus (HPV) for the prevention of diseases or infections associated with HPV, containing: HPV virus-like particles assembled from the L1 protein of HPV types 6, 11, 16, 18, 31, 33, 35, 39, 45, 52, 56, 58 and 59, characterized by the fact that at least one of these HPV virus-like particles is a chimeric HPV virus-like particle, wherein the chimeric HPV L1 protein includes, from its N-terminus to its C-terminus: a. An N-terminal fragment derived from L1 protein of papillomavirus type 1, wherein the said N-terminal fragment retains the immunogenicity of L1 protein of type 1 papillomavirus, wherein the said L1 protein of papillomavirus type 1 is selected from HPV types 6, 11, 16, 18, 31, 35, 39, 45, 51, 52, 56, 58 and one or more other pathogenic HPV types; and b. A C-terminal fragment derived from the papillomavirus type 2 L1 protein, wherein the papillomavirus type 2 L1 protein has a better expression level and solubility compared to other types of L1 proteins; wherein the said chimeric HPV L1 protein has the immunogenicity of the L1 protein of papillomavirus type 1. Also the following is described: a method of preventing HPV-associated disease or infection, comprising administering to a subject the said multivalent immunogenic HPV composition. The use of the specified multivalent immunogenic composition of HPV for the production of vaccines or medicinal products for the prevention of diseases or infections associated with HPV is presented.

EFFECT: invention is aimed at expanding the arsenal of means for preventing diseases or infections associated with HPV.

15 cl, 4 dwg, 18 tbl, 6 ex