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(19)

(11)

2 742 000

(13)

(51)

IPC

C07K14/705(2006-01-01)

C07K19/00(2006-01-01)

C12N5/783(2010-01-01)

C12N5/10(2006-01-01)

C12N15/09(2006-01-01)

A61K35/17(2015-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2019107136, 2019-03-13

(24)

Start date

2019-03-13

(22)

Actual filing date

2019-03-13

(45)

Published

2021-02-01

(72)

Inventor

Gershovich Pavel MikhajlovichKarabelskij Aleksandr VladimirovichUlitin Andrej BorisovichMadera Dmitrij AleksandrovichIvanov Roman AlekseevichMorozov Dmitrij Valentinovich

(73)

Holder

Obshchestvo S Ogranichennoj Otvetstvennostyu

ISOLATED ALTERNATIVE INTRACELLULAR SIGNALLING DOMAIN OF CHIMERIC ANTIGEN RECEPTOR AND CHIMERIC ANTIGEN RECEPTOR INCLUDING IT Russian patent published in 2021 - IPC C07K14/705 C07K19/00 C12N5/783 C12N5/10 C12N15/09 A61K35/17 A61P35/00

Abstract RU 2742000 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, in particular to obtaining chimeric antigen receptors (CAR) with a modified signalling CD3 zeta domain and can be used in medicine. The obtained CAR where in the signalling CD3-zeta domain one or two immunoreceptor tyrosine-based activation motifs (ITAM) selected from ITAM1, ITAM2 and ITAM3 are replaced with by a fragment of the amino acid sequence of integrin beta 3 (TIGB3) can be used to create modified T cells targeting tumor antigen used in effective cancer immunotherapy.

EFFECT: effective cancer immunotherapy.

64 cl, 29 dwg, 1 tbl, 6 ex

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RU 2 742 000 C2

Authors

Gershovich Pavel Mikhajlovich

Karabelskij Aleksandr Vladimirovich

Ulitin Andrej Borisovich

Madera Dmitrij Aleksandrovich

Ivanov Roman Alekseevich

Morozov Dmitrij Valentinovich

Dates

2021-02-01—Published

2019-03-13—Filed