NEW BIARYL DERIVATIVE USED AS INHIBITOR OF DIACYLGLYCEROL ACYLTRANSFERASE 2 AND ITS USE Russian patent published in 2023 - IPC C07D241/16 C07D401/04 C07D401/10 A61K31/216 A61K31/4965 A61K31/497 A61P1/16 A61P3/04 A61P3/06 A61P3/10 A61P9/10 

FIELD: organic chemistry.

SUBSTANCE: group of inventions includes a compound of formula (1), its pharmaceutically acceptable salt, stereoisomer and a pharmaceutical composition containing it. In formula (1), A, D and E are each independently CH or N; R₁ represents either C₁-C₇ alkyl, C₃-C₁₀ cycloalkyl or halogen-C₁-C₇ alkyl; R₂ represents -G-J-L; where G represents either -C(=O)- or direct bond; J represents C₁-C₇ alkylene, C₂-C₇ alkenylene, C₁-C₇ alkylene-C₆-C₁₀ arylene, C₂-C₇ alkenylene-C₆-C₁₀ arylene, C₁-C₇ alkoxyene-C₆-C₁₀ arylene, C₆-C₁₀ arylene, 5-12 membered heteroarylene-5-12 membered heterocycloalkylene, 5-12 member heteroarylene-C₆-C₁₀ arylene or 5-12 membered heteroarylene -oxy-C₃-C₁₀ cycloalkylene; L is either hydrogen, halogen, amino, nitro, carboxy, carboxy-C₁-C₇ alkyl, carboxy-C₁-C₇ alkoxy, C₃-C₁₀ cycloalkyl or C₆-C₁₀ aryl; wherein alkyl, alkylene, carboxyalkyl, carboxyalkoxy or aryl is optionally substituted with 1-4 substituents selected from hydroxy, halogen, C₁-C₇ alkyl and C₁-C₇ alkoxy; and heterocycloalkylene or heteroarylene includes 1–4 heteroatoms selected from N, O and S.

Formula (1)

EFFECT: obtaining a compound of formula (1), which exhibits diacylglycerol acyltransferase 2 (DGAT2) inhibitor activity.

4 cl, 1 tbl, 34 ex