COMPOUND FOR DESTRUCTION OF ANDROGEN RECEPTOR AND ITS PHARMACEUTICAL USE THEREOF Russian patent published in 2024 - IPC C07D401/14 C07D471/04 C07D471/10 C07D487/04 C07D487/10 C07D519/00 A61K31/444 A61K31/4545 A61K31/496 A61K31/497 A61K31/501 A61K31/506 A61P17/00 A61P17/02 A61P17/10 A61P17/14 A61P35/00 

FIELD: medicine; pharmaceutics.

SUBSTANCE: invention relates to a compound of Chemical formula 1 or a pharmaceutically acceptable salt thereof, which have the property of breaking down or inhibiting the androgen receptor (AR). In the formulas below, R₁ is H, halogen, haloC_1-6alkyl or C_1-6alkoxy, R₂ is H or C_1-4alkyl, X₁, X₃, X₄ and X₅ are each independently CH or N, X₂ is CR₃ or N, R₃ is H, C_1-6alkyl, halogen or -OH, n is 0, 1 or 2, m is 0 or 1, L represents Chemical formula 2, A₁, A₂ and A₃ each independently represents a direct bond, -O-, -N(R₄)-, -C(O)-, -CC-, -C(O)NH-, -NHC(O)-, -C(O)CH₂NH- or -C(O)CH₂O-, R₄ is H or C_1-6 alkyl, B₁, B₂ and B₃ each independently represent a direct bond or any of the following substitutes, each of R₄' independently represents H, C_1-4alkyl, halogenC_1-4alkyl, halogen or -OH, q1-q6 each independently represents integer from 0 to 4, E represents Chemical formula 3 or 4, X₆, X₇, X₈ and X₉ each independently represents CH or N, Y is -C(R₆)2-, -C(O)- or -N=N-, Z is a direct bond, -N(R₆) - or -C(O)NH-, R₅ and R₅' each independently represents H, C_1-4alkyl, halogen, halogenC_1-4alkyl or C_1-4alkoxy, each independently represents H, C_1-4alkyl or halogenC_1-4alkyl. Invention also relates to a pharmaceutical composition containing said compound or a pharmaceutically acceptable salt thereof, and to a method of treating or preventing an androgen receptor-related disease using the same.

EFFECT: destruction or inhibition of the androgen receptor.

9 cl, 6 tbl, 206 ex