FIELD: biotechnology.
SUBSTANCE: invention relates to a composition containing a recombinant adeno-associated virus (AAV) vector containing an AAV capsid that encapsulates a nucleotide of interest, and a polyspecific binding molecule containing an antibody paratope that specifically binds a heterologous epitope, and a retargeting ligand, which specifically binds a cell surface protein or marker, as well as a method of delivering the nucleotide of interest to a target cell expressing the cell surface protein using it.
EFFECT: invention is effective for targeted introduction of genetic material into a cell.
43 cl, 15 dwg, 3 tbl, 4 ex
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