NEW NITROGEN-SUBSTITUTED 2,4,5-TRI(METHOXYPHENYL) CIS-IMIDAZOLINES, METHOD OF THEIR PREPARATION AND USE Russian patent published in 2023 - IPC C07D233/22 A61K31/4164 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to new nitrogen-substituted derivatives of 2,4,5-tris(alkoxyphenyl)-cis-imidazolines, general formula I, a method of their preparation, use and a pharmaceutical composition based on them.

EFFECT: obtaining new compounds with the ability to stabilize p53 protein levels for the treatment of oncological diseases

,

I

where R₁ = 2-methoxyphenyl, 4-methoxyphenyl, 3,4-dimethoxyphenyl, 2,4-dimethoxyphenyl, 3,5-dimethoxyphenyl, 4-chlorophenyl or 2,4-dichlorophenyl. R₂ = alkylamines such as piperidine, morpholine, diethylamine, pyrrolidine, piperazine, azepane, which may be substituted with methyl or tert-butyl carboxyl group.

17 cl, 1 dwg, 1 tbl