FIELD: organic chemistry; pharmaceuticals.
SUBSTANCE: pheospheride derivatives with antitumor activity. Specific compounds presented in cl. 1 of the claims are proposed. In addition, a pharmaceutical composition is disclosed containing at least one compound according to cl. 1 in an effective amount and having cytotoxic and/or antitumor activity, and/or the ability to overcome the drug resistance of tumor cells to drugs, as well as the use of these compounds in as agents with cytotoxic and/or antitumor activity, and/or the ability to overcome drug resistance of tumor cells to drugs.
EFFECT: providing pronounced cytotoxic, antitumor activity of the compounds, as well as their ability to overcome the drug resistance of tumor cells to drugs.
4 cl, 6 tbl, 15 ex
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