METHOD OF PREOPERATIVE CORRECTION OF ANEMIA IN PATIENTS WITH COLORECTAL CANCER WITH LIVER METASTASES Russian patent published in 2024 - IPC A61K38/22 A61K33/26 A61K31/5375 A61K31/727 A61P7/06 

FIELD: medicine; transfusiology; surgery; oncology.

SUBSTANCE: invention can be used for preoperative correction of anemia in patients with colorectal cancer with liver metastases. The method includes the administration of Darbopoietin alfa and an iron agent. Darbopoetin alfa is administered 21 days before surgery once subcutaneously in an amount of 6.75 mcg/kg, iron (III) hydroxide oligoisomaltose as an iron agent is administered in an amount of 20 mg/kg once intravenously 21 days before surgery. Additionally, 21 days before surgery, oral administration of the anticoagulant Rivaroxaban 10 mg daily for 16 days is prescribed, after which daily subcutaneous administration of low molecular weight heparin — Enoxaparin Sodium 40 mg-4000 anti Xa ME — is performed for five days.

EFFECT: invention makes it possible to stimulate erythropoiesis in the preoperative period in patients with colorectal cancer with metastatic liver disease and minimizes the risk of thromboembolic complications.

1 cl, 2 ex