FIELD: biotechnology.
SUBSTANCE: following are presented: polypeptide compositions for expansion of Tregs, one of which contains a variant human IL-2 protein, in which the said variant IL-2 protein contains one or more amino acid substitutions compared to SEQ ID NO:2, selected from the group T3A/D20N/T37R, T3A/D20N/N71K, T3A/D20N/T37R/C125S, T3A/D20N/N71K/C125S, T3A/D20N/T37R/C125A and T3A/D20N/N71K/C125A. The following are also disclosed: Tregs expansion polypeptide compositions containing a heterodimeric Tregs expansion protein complex.
EFFECT: invention provides selective and sustainable expansion of Treg.
13 cl, 145 dwg, 145 ex
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