METHOD OF PRODUCING MONODISPERSE SPHERICAL PARTICLES OF POLYMETHYL METHACRYLATE OF GIVEN SIZE Russian patent published in 2024 - IPC C08F2/18 C08F20/18 

FIELD: technological processes.

SUBSTANCE: invention relates to a method of producing monodisperse spherical polymer particles, particularly polymethyl methacrylate (PMMA), of a given diameter. Invention can be used in colloidal chemistry, biotechnology, medicine as carriers of functional components, templates when producing more complex nano- and microparticles, calibration standards in analysis of variance. Method of producing monodisperse spherical particles of polymethyl methacrylate of a given size is based on emulsion polymerisation of methyl methacrylate (MMA) in an aqueous medium while heating. Obtaining is carried out in two stages: at the first one synthesizes particles that are deliberately smaller than a given size, at the second stage, particles are grown to a given final diameter by adding an additional amount of methyl methacrylate. Additional amount of MMA is calculated by formula

where m_ext is the calculated weight of methyl methacrylate for growing polymethyl methacrylate particles (g), m is the weight of the grown polymethyl methacrylate particles (g), m_w is the weight of water added at the growing step, (g), D is the target diameter of the methyl methacrylate particles (nm), d is the diameter of the polymethyl methacrylate particles obtained at the previous growth stage, (nm).

EFFECT: proposed invention enables to obtain polymer spherical particles of PMMA with a predetermined diameter in range of 200–1,200 nm with standard deviation of not more than 5 %.

1 cl, 2 dwg, 1 tbl, 4 ex