COMBINATION OF LSD1 INHIBITORS FOR TREATING HAEMATOLOGICAL MALIGNANT DISEASES Russian patent published in 2024 - IPC A61K31/135 A61K31/00 A61P35/00 

Abstract RU 2816659 C2

FIELD: medicine.

SUBSTANCE: group of inventions relates to the treatment of haematological malignant diseases. Combination for treating a hyperproliferative disorder contains a compound of formula (I) or a pharmaceutically acceptable salt thereof, a BCL2 inhibitor selected from venetoclax, ABT-737 and pharmaceutically acceptable salts thereof.

Also disclosed are a pharmaceutical composition, a kit, methods of treating a hyperproliferative disorder, using a combination for treating a hyperproliferative disorder and for preparing a drug.

EFFECT: group of inventions provides achieving a synergetic effect on cancer cell inhibition.

40 cl, 22 dwg, 4 tbl, 2 ex

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RU 2 816 659 C2

Authors

Ciceri Filippo

Lunardi Serena

Maes Tamara

Mascaro Crusat Cristina

Tirapu Fernandez De La Cuesta Inigo

Dates

2024-04-02Published

2017-03-13Filed