FIELD: biotechnology.
SUBSTANCE: to inhibit cell proliferation and initiation of apoptosis in human a CHK1 inhibitor is used which is (R)-N-(4-(3-aminopiperidin-1-yl)-5-brom-1H-pyrrol[2,3-b]pyridin-3-yl)isobutyramide, in combination with WEE1 inhibitor, which is MK-1775.
EFFECT: group of inventions provides a dosage regimen, which is the minimum amount to achieve a given biological effect without side effects.
4 cl, 9 dwg, 6 ex
| Title |
Year |
Author |
Number |
| INTERMEDIATE CHEMICAL COMPOUNDS AND METHODS FOR PRODUCING COMPOUNDS |
2013 |
|
RU2635359C2 |
| INHIBITORS OF CELL CYCLE CHECKPOINT KINASE 1 FOR AMPLIFICATION OF DNA-DAMAGING AGENTS |
2010 |
- Khamfris Majkl Dzh.
- Vinski Shannon L.
|
RU2567044C2 |
| METHOD OF TREATING CANCER USING A COMBINATION OF CHK1 AND ATR INHIBITORS |
2015 |
- Helleday, Thomas
- Sanjiv, Kumar
|
RU2736219C2 |
| COMBINED THERAPY WITH (2R,Z)-2-AMINO-2-CYCLOHEXYL-N-(5-(1-METHYL-1H-PIRAZOLE-4-YL)-1-OXO-2,6-DIHYDRO-1H-[1,2]DIAZEPINO[4,5,6-cd]INDOLE-8-YL)ACETAMIDE |
2007 |
- Ehnderes Kenna Linn
- Blazina Alessandra
|
RU2409361C2 |
| METHOD OF PREPARING COMPOUND |
2014 |
- Khan Chun
- Grin Kenna
- Gosselen Fransis
- Skalone Mikelandzhelo
- Nikols Pol Dzh.
- Lyu Vejdun
- Spenser Kejt L.
- Krejn Zakari D.
- Stendzhel Piter Dzh.
- Shakya Sagar
|
RU2672725C2 |
| 5-[[4-[[MORPHOLIN-2-YL]METHYLAMINO]-5-(TRIFLUOROMETHYL)-2-PYRIDYL]AMINO]PYRAZINE-2-CARBONITRILE, THERAPEUTIC USES THEREOF |
2013 |
- Kollins Yan
- Mettyus Tomas Piter
- Fariya Da Fonseka Makkhardi Tatyana
- Ozborn Dzhejms
- Lejnchbari Majkl
- Uolton Majkl Yan
- Garrett Mishel Doun
|
RU2659786C2 |
| AMINOPYRIMIDINES AS KINASE INHIBITORS |
2006 |
- Binch Khehjli
- Mortimor Majkl
- Frajss Dam'En
- Rezerford Ehlister
|
RU2427578C2 |
| COMBINATION OF A HISTONE DEACETYLASE INHIBITOR AND A PROTEIN KINASE INHIBITOR AND PHARMACEUTICAL APPLICATION THEREOF |
2019 |
- Lu, Xianping
- Ning, Zhiqiang
- Zhou, You
- Xin, Lijun
- Wang, Yanan
- Wang, Shigang
- Pan, Desi
- Shan, Song
|
RU2770754C1 |
| POLYMORPHS OF KINASE INHIBITOR |
2012 |
|
RU2636588C2 |
| PHARMACEUTICAL COMBINATION COMPRISING INHIBITOR PHOSPHATYLENOSITOL 3-KINASES AND AROMATASE INHIBITOR |
2013 |
- Goldbrunner Mikhael
- Khuan Sichzhun
|
RU2651023C2 |
