METHOD OF PRODUCING ETHYL-3-AMINO-1-[(3R,4S)-4-CYANOTETRAHYDROPYRAN-3-YL]PYRAZOLE-4-CARBOXYLATE BY CHIRAL SEPARATION OF RACEMIC MIXTURE Russian patent published in 2024 - IPC C07D405/04 

Abstract RU 2817543 C2

FIELD: chemical or physical processes.

SUBSTANCE: invention relates to a method for chiral extraction of ethyl-3-amino-1-[(3R,4S)-4-cyanotetrahydropyran-3-yl]pyrazole-4-carboxylate (VI) from a racemic mixture of ethyl-3-amino-1-[(3R,4S)-4-cyanotetrahydropyran-3-yl]pyrazole-4-carboxylate and ethyl-3-amino-1-[(3S,4R)-4-cyanotetrahydropyran-3-yl]pyrazole-4-carboxylate (V).

EFFECT: method enables efficient separation of enantiomers with both high efficiency and high selectivity.

17 cl, 3 tbl, 3 ex

Similar patents RU2817543C2

Title Year Author Number
METHOD FOR PREPARATIVE SEPARATION OF RACEMIC SALBUTAMOL BASE USING SUPERCRITICAL FLUID CHROMATOGRAPHY 2019
  • Sysoev Aleksandr Vladimirovich
  • Tsarev Vitalij Nikolaevich
  • Bazarnova Natalya Grigorevna
  • Kushnir Evgenij Yurevich
  • Gensh Konstantin Viktorovich
  • Cheprasova Marina Yurevna
  • Mikushina Irina Vladimirovna
  • Sysoeva Aleksandra Viktorovna
RU2727890C1
2-OXA-5-AZABICYCLO[2.2.1]HEPTANE-3-YL DERIVATIVES 2015
  • Chechere Dzhuzeppe
  • Gallej Guido
  • Khu Imin
  • Norkross Rodzher
  • Pfliger Filipp
  • Shen Khun
RU2697651C2
N-(2-CYANO HETEROCYCLYL)PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS 2014
  • Dinsmor, Kristofer
  • Fuller, Piter
  • Gerin, Devid
  • Tompson, Kristofer F.
  • Pu, Tsinlin
  • Skott, Mark E.
  • Katts, Dzhejson Devid
  • Kurukulasuriya, Ravi
  • Klouz, Dzhoshua T.
  • Folkon, Deniell
  • Brubejker, Dzhejson
  • Tszen, Khunbo
  • Baj, Yunfyn
  • Fu, Tszyanmin
  • Kun, Norman
  • Lyu, Yujmej
  • Chzhen, Chzhisyan
RU2669922C2
PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS FOR APPLICATION 2012
  • Khodzhz Alaster Dzh.
  • Matteuchchi Mitsio
  • Sharp Endryu
  • San Minkhua
  • Tsui Viki Kh.
  • Van Syaotszin
RU2638552C2
NEW IMIDAZO[4,5-c]QUINOLINE DERIVATIVES AS LRRK2 INHIBITORS 2018
  • Brodney Michael Aaron
  • Chappie Thomas Allen
  • Chen Jinshan Michael
  • Coe Jotham Wadsworth
  • Coffman Karen Jean
  • Galatsis Paul
  • Garnsey Michelle Renee
  • Helal Christopher John
  • Henderson Jaclyn Louise
  • Kormos Bethany Lyn
  • Kurumbail Ravi G.
  • Martinez-Alsina Luis Angel
  • Pettersson Martin Youngjin
  • Reese Matthew Richard
  • Rose Colin Richard
  • Stepan Antonia Friederike
  • Verhoest Patrick Robert
  • Wager Travis T.
  • Warmus Joseph Scott
  • Zhang Yuan
RU2773516C2
PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA 2013
  • Achab Abdelgkhani Abe
  • Altman Majkl D.
  • Deng Jongki
  • Kattar Solomon
  • Katts Dzhejson D.
  • Metot Dzhon L.
  • Chzhou Khua
  • Makgovan Meredet
  • Kristofer Mettyu P.
  • Garsiya Yudit
  • Entoni Nevill Dzhon
  • Fradera Linas Fransesk Ksaver
  • Yan Lipin
  • Mu Chanvej
  • Van Syaona
  • Shi Fen
  • E Bajtszyun
  • Chzhan Sisin
  • Chzhao Syaoli
  • Chzhan Zhun
  • Fong Kin Chiu
  • Len Syanshen
RU2661896C2
STEREOISOMERICALLY ENRICHED 3-AMINOCARBONYL BICYCLOHEPETENE PYRIMIDINE DIAMINES AND USE THEREOF 2005
  • Argade Ankush
  • Singkh Radzhinder
  • Li Khoj
RU2416604C2
3-CARBONYLAMINO-5-CYCLOPENTYL-1H-PYRAZOLE COMPOUNDS WITH CDK2 INHIBITOR ACTIVITY 2020
  • Behenna, Douglas Carl
  • Freeman-Cook, Kevin Daniel
  • Hoffman, Robert Louis
  • Nagata, Asako
  • Ninkovic, Sacha
  • Sutton, Scott Channing
RU2797889C2
NEW DERIVATIVES OF IMIDAZO [4,5-C] QUINOLINES AND IMIDAZO [4,5-C] [1,5] NAPHTHYRIDINES AS LRRK2 INHIBITORS 2016
  • Galatsis Paul
  • Henderson Jaclyn Louise
  • Kormos Bethany Lyn
  • Kurumbail Ravi G.
  • Reese Matthew Richard
  • Stepan Antonia Friederike
  • Verhoest Patrick Robert
  • Wager Travis T.
  • Pettersson Martin Youngjin
  • Garnsey Michelle Renee
RU2722149C1
6-[4-(1H-IMIDAZOL-2-YL)PIPERIDIN-1-YL]PYRIMIDIN-4-AMINE DERIVATIVES AS MODULATORS OF KINASE ACTIVITY 2014
  • Lan Zhosi
  • Chen Syaolin
  • Syao Yujfan
  • Khak Bajard R.
  • Goutopoulos Andreas
RU2674261C2

RU 2 817 543 C2

Authors

Chassaing, Christophe, Pierre, Alain

Grimm, Karl-Heinz

Dates

2024-04-16Published

2020-05-01Filed