FIELD: chemical or physical processes.
SUBSTANCE: invention relates to a method for chiral extraction of ethyl-3-amino-1-[(3R,4S)-4-cyanotetrahydropyran-3-yl]pyrazole-4-carboxylate (VI) from a racemic mixture of ethyl-3-amino-1-[(3R,4S)-4-cyanotetrahydropyran-3-yl]pyrazole-4-carboxylate and ethyl-3-amino-1-[(3S,4R)-4-cyanotetrahydropyran-3-yl]pyrazole-4-carboxylate (V).
EFFECT: method enables efficient separation of enantiomers with both high efficiency and high selectivity.
17 cl, 3 tbl, 3 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD FOR PREPARATIVE SEPARATION OF RACEMIC SALBUTAMOL BASE USING SUPERCRITICAL FLUID CHROMATOGRAPHY | 2019 |
|
RU2727890C1 |
2-OXA-5-AZABICYCLO[2.2.1]HEPTANE-3-YL DERIVATIVES | 2015 |
|
RU2697651C2 |
N-(2-CYANO HETEROCYCLYL)PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | 2014 |
|
RU2669922C2 |
PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS FOR APPLICATION | 2012 |
|
RU2638552C2 |
NEW IMIDAZO[4,5-c]QUINOLINE DERIVATIVES AS LRRK2 INHIBITORS | 2018 |
|
RU2773516C2 |
PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | 2013 |
|
RU2661896C2 |
STEREOISOMERICALLY ENRICHED 3-AMINOCARBONYL BICYCLOHEPETENE PYRIMIDINE DIAMINES AND USE THEREOF | 2005 |
|
RU2416604C2 |
3-CARBONYLAMINO-5-CYCLOPENTYL-1H-PYRAZOLE COMPOUNDS WITH CDK2 INHIBITOR ACTIVITY | 2020 |
|
RU2797889C2 |
NEW DERIVATIVES OF IMIDAZO [4,5-C] QUINOLINES AND IMIDAZO [4,5-C] [1,5] NAPHTHYRIDINES AS LRRK2 INHIBITORS | 2016 |
|
RU2722149C1 |
6-[4-(1H-IMIDAZOL-2-YL)PIPERIDIN-1-YL]PYRIMIDIN-4-AMINE DERIVATIVES AS MODULATORS OF KINASE ACTIVITY | 2014 |
|
RU2674261C2 |
Authors
Dates
2024-04-16—Published
2020-05-01—Filed