FIELD: biotechnology.
SUBSTANCE: present invention relates to novel therapeutic peptides and can be used in medicine. Invention discloses a new peptide analogue of glucose-dependent insulinotropic polypeptide (GIP), modified by inclusion of one or more separate amino acid substitutions and conjugated with a fatty acid with or without a linker to provide increased antagonist activity and an improved pharmacokinetic profile.
EFFECT: invention can be used in medical practice for prevention or treatment of various metabolic diseases.
15 cl, 1 dwg, 3 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
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