FIELD: biotechnology.
SUBSTANCE: monoclonal antibody or its antigen-binding fragment, which specifically bind human tau-protein, its production and use are proposed. The antibody contains HCDR1 according to SEQ ID NO: 732, HCDR2 according to SEQ ID NO: 734, HCDR3 according to SEQ ID NO: 736, and LCDR1 according to SEQ ID NO: 846, LCDR2 according to SEQ ID NO: 848, LCDR3 according to SEQ ID NO: 850, as defined according to Kabat method. Alternatively, a heavy chain contains HCDR1 according to SEQ ID NO: 1002, HCDR2 according to SEQ ID NO: 1004, and HCDR3 according to SEQ ID NO: 1006, and a light chain contains LCDR1 according to SEQ ID NO: 1116, LCDR2 according to SEQ ID NO: 1118, and LCDR3 according to SEQ ID NO: 1120.
EFFECT: antibody or its antigen-binding fragment are used for reduction in levels of sarkosyl-insoluble tau-protein in a subject and in the treatment of tauopathy.
40 cl, 33 dwg, 15 tbl, 19 ex
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