FIELD: biotechnology; medicine.
SUBSTANCE: invention relates to biotechnology, immunology and medicine, in particular to new non-selective and artificial epitopes of T-helper cells (Th-epitopes), designed to ensure optimal immunogenicity of the target antigenic site. Target antigenic site may include a B-cell epitope, a CTL epitope, a peptide hapten, a non-peptide hapten or any immunologically reactive analogue thereof. Described Th-epitopes, when covalently linked to a target antigenic site in a peptide immunogenic structure, cause a strong B-cell immune response or an effector T-cell response to the target antigenic site.
EFFECT: invention provides effective and safe peptide immunogens which, after administration, do not cause inflammatory cell-mediated immune responses against self-antigens.
11 cl, 21 dwg, 15 tbl, 12 ex
| Title |
Year |
Author |
Number |
| PEPTIDE IMMUNOGENS TARGETING INTERLEUKIN 6 (IL-6) AND COMPOSITIONS THEREOF FOR IMMUNOTHERAPY OF DISEASES AFFECTED BY IMPAIRED IL-6 REGULATION |
2019 |
- Wang, Chang, Yi
- Lin, Feng
- Chen, Jiun, Bo
- Ding, Shuang
|
RU2780161C1 |
| TAU-PEPTIDE IMMUNOGENIC CONSTRUCTS |
2018 |
|
RU2798972C2 |
| IL-31 PEPTIDE IMMUNOGENS AND THEIR COMPOSITIONS FOR THE TREATMENT AND/OR PREVENTION OF ADOPIC DERMATITIS |
2018 |
|
RU2799440C2 |
| PEPTIDE IMMUNOGENS FROM C-TERMINAL END OF ALPHA-SYNUCLEIN PROTEIN AND COMPOSITIONS BASED ON THEM FOR TREATMENT OF SYNUCLEONOPATHIES |
2018 |
|
RU2810774C2 |
| PEPTIDE IMMUNOGENS AND COMPOSITIONS CONTAINING SAID IMMUNOGENS TARGETING MEMBRANE-BOUND IGE FOR TREATING IGE-MEDIATED ALLERGIC DISEASES |
2017 |
- Wang, Chang Yi
- Lin, Feng
- Chen, Jiun Bo
|
RU2769983C2 |
| ADAM9-BINDING MOLECULES AND THEIR APPLICATION METHODS |
2017 |
- Lu, Derik, T.
- Skrajbner, Dzhuniper, A.
- Barat, Bkhasvati
- Didrich, Gundo
- Dzhonson, Lesli, S.
- Bonvini, Ezio
|
RU2783619C2 |
| RSV F MUTANT PROTEIN AND ITS APPLICATION |
2020 |
- Hogiri, Tomoharu
- Kishida, Hiroyuki
- Takedomi, Kei
- Branduardi, Davide
- Oloo, Eliud
- Feyfant, Eric
- Ichihara, Osamu
|
RU2807742C1 |
| SYSTEM FOR PRESENTATION OF PEPTIDES ON CELL SURFACE |
2016 |
|
RU2739593C2 |
| VACCINE CONSTRUCTS AND THEIR APPLICATIONS AGAINST STAPHYLOCOCCUS INFECTIONS |
2017 |
- Maluen, Fransua
- Ster, Selin
- Kote-Gravel, Zhyuli
- Brujett, Erik
|
RU2766354C2 |
| ANTIBODIES TO TAU AND THEIR USE |
2018 |
- Roberts, Malkolm Yan
- Staddon, Dzhejms Martin
- De Silva, Khettikhevejdzh Alfred Roan
- Spajdel, Dzhared
- Aojagi, Khirofumi
- Akasofu, Shigeru
- Khashizume, Yutaka
- Agarvala, Kishan
|
RU2787779C2 |
