FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to recombinant production of neuroprotective proteins, and can be used in medicine for treating stroke. Hybrid protein comprising a sequence of insulin-like growth factor 1 (IGF-1) or an isoform thereof, having neuroprotective activity, to which from the C-terminal is attached directly or through a linker, the sequence SEQ ID NO: 3. Invention also relates to a nucleic acid, a vector, a host cell, a pharmaceutical composition, a method of treating stroke and use based on said protein.
EFFECT: invention enables to obtain a neuroprotective protein named by the authors "IGF-1-long", characterized by a longer therapeutic effect compared to IGF-1, not fused with an additional domain.
16 cl, 3 tbl, 3 ex
| Title |
Year |
Author |
Number |
| METHOD FOR TREATING MULTIPLE SCLEROSIS (VERSIONS) |
2017 |
- Dukhovlinov Ilya Vladimirovich
|
RU2721282C2 |
| FUSION PROTEIN, DNA, GENETIC CONSTRUCT, RECOMBINANT CELL, FUSION PROTEIN-BASED VACCINE FOR TUBERCULOSIS PREVENTION AND TREATMENT (VERSIONS) |
2015 |
- Dukhovlinov Ilya Vladimirovich
- Orlov Anton Iosifovich
- Fedorova Ekaterina Alekseevna
- Chernyaeva Ekaterina Nikolaevna
|
RU2615440C2 |
| CHIMERIC PROTEIN, A SYNTHETIC DNA WHICH CODES SAID PROTEIN, AN EXPRESSION VECTOR, A SYNTHETIC DNA PRODUCING STRAIN AND A METHOD OF PRODUCING PLASMID DNA |
2016 |
- Dukhovlinov Ilya Vladimirovich
|
RU2736472C2 |
| ANALGETIC AGENT ON THE BASIS OF PLASMID DNA CODING HNP-1, OR HNP-2, OR HNP-3 (VERSIONS) |
2014 |
- Dukhovlinov Ilya Vladimirovich
- Orlov Anton Iosifovich
|
RU2597789C2 |
| VACCINE FOR THE PREVENTION OR TREATMENT OF CORONAVIRUS INFECTION BASED ON A GENETIC CONSTRUCT |
2020 |
- Dukhovlinov Ilya Vladimirovich
- Fedorova Ekaterina Alekseevna
- Kolmakov Nikolay Nikolaevich
- Chirak Evgeniy Leonidovich
- Alekseev Aleksey Viktorovich
|
RU2747762C1 |
| METHOD FOR TREATMENT OR PREVENTION OF STROKE |
2015 |
- Eriksson Ulf
- Nilsson Ingrid
- Lourens Deniel
- Su Enmin Dzho
|
RU2744909C2 |
| VERSIONS OF ERYTHROPOETINE |
2006 |
- Majzel' Andreas
- Priller Jozef
- Bonnas Kristel'
- Dirnagl' Ul'Rikh
|
RU2430162C2 |
| TREATING AND PREVENTING CARDIAC DISEASES WITH USING TWO OR MORE ISOFORMS OF HEPATOCYTE GROWTH FACTOR |
2009 |
- Kim Dzong-Mook
- Kim Sudzeong
- Khan Voong
|
RU2448159C1 |
| SYSTEM DELIVERY AND REGULATED EXPRESSION OF PARACRINE GENES FOR TREATMENT OF CARDIOVASCULAR AND OTHER DISEASES |
2013 |
- Khemmond Kh. Kerk
- Gao Mej Khua
|
RU2642605C2 |
| PHARMACEUTICAL COMPOSITION FOR GENETIC THERAPY OF DISEASES REQUIRING STIMULATION OF REGENERATIVE PROCESSES, INCLUDING HUMAN TISSUE DAMAGES OF VARIOUS AETIOLOGIES, BASED ON SYNTHETIC MODIFIED GENE OF INSULIN-LIKE HUMAN GROWTH FACTOR TYPE ONE (IFR-1, IGF-1) |
2007 |
- Ivanov Igor' Al'Bertovich
|
RU2372941C2 |
