FIELD: biotechnology.
SUBSTANCE: invention relates to heterodimeric Fc fusion proteins. Disclosed are heterodimeric Fc fusion proteins for inducing T-cell proliferation, in which Fc domains contain modifications facilitating their heterodimerisation. Invention provides producing IL-12 heterodimer in form of fused proteins with Fc with enhanced circulation in blood, in which to eliminate antagonist action of subunit IL-12p40 formed preliminary complex of subunits IL-12p40 and IL-12p35, and also reduced activity of IL-12 variants for improving pharmacokinetics and therapeutic index.
EFFECT: invention can be used to induce reproduction of T-cells.
24 cl, 67 dwg, 1 tbl, 8 ex
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