IL-12 HETERODIMERIC FC FUSION PROTEINS Russian patent published in 2024 - IPC C07K14/54 C07K19/00 C12P21/02 A61K38/20 A61K47/68 

Abstract RU 2819097 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to heterodimeric Fc fusion proteins. Disclosed are heterodimeric Fc fusion proteins for inducing T-cell proliferation, in which Fc domains contain modifications facilitating their heterodimerisation. Invention provides producing IL-12 heterodimer in form of fused proteins with Fc with enhanced circulation in blood, in which to eliminate antagonist action of subunit IL-12p40 formed preliminary complex of subunits IL-12p40 and IL-12p35, and also reduced activity of IL-12 variants for improving pharmacokinetics and therapeutic index.

EFFECT: invention can be used to induce reproduction of T-cells.

24 cl, 67 dwg, 1 tbl, 8 ex

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RU 2 819 097 C2

Authors

Bernett, Matthew

Desjarlais, John, R

Varma, Rajat

Liu, Ke

Hassanzadeh-Kiabi, Nargess

Rashid, Rumana

Dates

2024-05-14Published

2019-10-03Filed