FIELD: biotechnology.
SUBSTANCE: antibody construct is proposed to improve the pharmacokinetics of an insert polypeptide, containing a frame antibody that contains a variable (V) domain and an insert polypeptide. The insert polypeptide is located in the framework region 3 of the V domain. Nucleic acids, expression vectors, cloning vectors, and host cells for producing the said antibody construct are also provided.
EFFECT: invention provides a new format of engineered antibody which demonstrates improved pharmacokinetics, for example, increased serum half-life.
32 cl, 24 dwg, 7 tbl, 15 ex
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