FIELD: biotechnology.
SUBSTANCE: antibody construct is proposed to improve the pharmacokinetics of an insert polypeptide, containing a frame antibody that contains a variable (V) domain and an insert polypeptide. The insert polypeptide is located in the framework region 3 of the V domain. Nucleic acids, expression vectors, cloning vectors, and host cells for producing the said antibody construct are also provided.
EFFECT: invention provides a new format of engineered antibody which demonstrates improved pharmacokinetics, for example, increased serum half-life.
32 cl, 24 dwg, 7 tbl, 15 ex
Title | Year | Author | Number |
---|---|---|---|
C3 BINDING AGENTS AND METHODS OF THEIR USE | 2019 |
|
RU2802307C2 |
CONNECTIVE TISSUE GROWTH FACTOR ANTIBODY AND USE THEREOF | 2020 |
|
RU2819228C2 |
BISPECIFIC ANTIBODY AGAINST RABIES VIRUS AND ITS APPLICATION | 2019 |
|
RU2764740C1 |
IMMUNOCYTOKINES AND THEIR USE | 2021 |
|
RU2818371C1 |
CYTOTOXICITY-INDUCING THERAPEUTIC AGENT | 2015 |
|
RU2743464C2 |
COMPOSITION FOR PREVENTION AND TREATMENT OF SKIN DISEASE CONTAINING SUBSTANCE SPECIFICALLY BINDING WITH VIMENTINE DERIVATIVE PEPTIDE | 2018 |
|
RU2751486C1 |
IL4/IL13 RECEPTOR MOLECULE FOR VETERINARY USE | 2018 |
|
RU2795591C2 |
CD47-ANTIGEN-BINDING UNIT AND ITS USE | 2018 |
|
RU2780859C2 |
CD40 LIGAND THERAPEUTIC ANTIBODIES | 2018 |
|
RU2770209C2 |
ANTI-PCSK9 ANTIBODY, ITS ANTIGEN-BINDING DOMAIN AND MEDICAL APPLICATION THEREOF | 2016 |
|
RU2739208C2 |
Authors
Dates
2023-05-18—Published
2019-07-10—Filed