FIELD: chemistry.
SUBSTANCE: invention relates to biochemistry, in particular to a genetically modified mouse which expresses hSIRPα protein, and wherein hSIRPα protein has SIRPα receptor function wild type human and contains the signalling domain of the endogenous murine protein SIRPα, and also expresses hIL-15 protein, and hIL-15 protein has signalling function of human IL-15 wild type.
EFFECT: invention makes it possible to efficiently simulate development and functioning of human natural killer cells (KC).
29 cl, 25 dwg, 1 tbl, 10 ex
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