FIELD: biotechnology.
SUBSTANCE: provided are animals other than humans, and methods and compositions for producing and using said animals, wherein said animals other than humans contain a humanised endogenous differentiation cluster (CD) gene, particularly a humanised CD47 gene.
EFFECT: said non-human animals, in some embodiments, can be described as having a genetic modification of the endogenous CD47 gene, such that said non-human animals express a CD47 polypeptide which contains a human portion and a non-human portion (for example, a murine portion).
9 cl, 9 dwg, 6 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| ANIMALS OTHER THAN HUMANS HAVING A HUMANISED CLUSTER GENE OF DIFFERENTIATION 47 | 2015 |
|
RU2728412C2 |
| FUSION PROTEIN AND ITS USE | 2020 |
|
RU2811120C2 |
| HUMANIZED MICE WITH SIRPA-IL15 KNOCKIN AND METHODS OF USE THEREOF | 2016 |
|
RU2822370C2 |
| ANTI-SIRPα ANTIBODY AND USE THEREOF | 2021 |
|
RU2822496C1 |
| FUNCTION PROTEIN AND ITS USE | 2019 |
|
RU2800923C2 |
| Therapeutic antibodies to CD47 | 2016 |
|
RU2748401C2 |
| ANTIBODY AGAINST SIRPα | 2019 |
|
RU2791002C2 |
| EMBODIMENTS OF SIRP-ALPHA-4-1BBL FUSION PROTEIN AND METHODS OF USE THEREOF | 2019 |
|
RU2815515C2 |
| FUSED PROTEIN SIRPΑ-4-1BBL AND METHODS OF USING SAME | 2018 |
|
RU2769769C2 |
| CD47-ANTIGEN-BINDING UNIT AND ITS USE | 2018 |
|
RU2780859C2 |
