FIELD: biochemistry.
SUBSTANCE: invention relates to rodent for expression of humanised polypeptide CD47, to its cell, tissue and embryo, as well as to a method for producing said rodent. Also disclosed is a method of assessing engraftment of human cells using said rodent. Invention also relates to a method for assessing the therapeutic efficacy of a medicament specifically targeted on human cells, as well as a method of assessing, induces human CD47 protein modulator to induce erythrocyte agglutination. Above methods provide for the use of a rodent expressing a humanized CD47 polypeptide.
EFFECT: invention enables effective identification and development of new therapeutic agents for cancer.
18 cl, 9 dwg, 6 tbl, 5 ex
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