FIELD: experimental medicine; nephrology.
SUBSTANCE: invention can be used to simulate mineral and bone disorders in chronic kidney disease (MBD–CKD) in laboratory rats. In spontaneously hypertensive SHR rats with arterial hypertension, 3/4 of the volume of kidneys is removed. After 2 or 6 months of the experiment, models of early stages of mineral and bone disorders corresponding to CKD stage 1 or 2 in humans are obtained.
EFFECT: method enables to simulate the spectrum of early MBD–CKD stages corresponding to stage 1–2 CKD in a human, with changes in the histology and molecular biology of bone tissue and myocardium, which, in turn, makes it possible to apply the model for studying the pathogenesis of MBD–CKD, for developing new methods of diagnosing, preventing and treating diseases of the cardiovascular system and skeleton associated with chronic kidney disease.
1 cl, 1 ex
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