FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to the use of peptide inhibitors of ActRIIB, and can be used in medicine for the treatment of atherosclerotic calcification.
EFFECT: invention allows to reduce or alleviate one or more symptoms of vascular calcification in an individual, such as an increase in vascular calcium levels, increased apoptosis of vascular smooth muscle cells, loss of elasticity of the arteries, an increase in the speed of the pulse wave, the development of left ventricular hypertrophy, a decrease in perfusion of the coronary arteries and myocardial ischemia.
14 cl, 11 dwg, 6 tbl, 1 ex
| Title |
Year |
Author |
Number |
| COMPOSITIONS AND METHODS OF PULMONARY HYPERTENSION TREATMENT |
2017 |
- Kumar, Ravindra
- Knopf, John
|
RU2748278C2 |
| NOVEL HYBRID ACTRIIB LIGAND TRAP PROTEINS FOR TREATING DISEASES ASSOCIATED WITH MUSCULAR ATROPHY |
2016 |
|
RU2733492C2 |
| ACTIVIN-ActRIIa-Fc ANTAGONISTS AND USE THEREOF FOR TREATING OR PREVENTING BREAST CANCER |
2008 |
- Nopf Dzhon
- Sikhra Dzhasbir
- Kumar Ravindra
|
RU2473362C2 |
| COMBINED APPLICATION OF TRAPS OF GDF AND ERYTHROPOIETIN RECEPTOR ACTIVATORS FOR INCREASING ERYTHROCYTE CONTENT |
2010 |
- Sikhra Dzhasbir
- Pirsall Robert Skott
- Kumar Ravindra
|
RU2592670C2 |
| COMBINED USE OF GDF TRAPS AND ACTIVATORS OF ERYTHROPOIETIN RECEPTORS TO INCREASE ERYTHROCYTE CONTENT |
2017 |
- Seehra, Jasbir
- Pearsall, Robert, Scott
- Kumar, Ravindra
|
RU2732229C2 |
| COMBINED ADMINISTRATION OF GDF TRAPS AND ERYTHROPOETIN RECEPTOR ACTIVATORS FOR INCREASING CONTENT OF ERYTHROCYTES |
2010 |
- Sikhra Dzhasbir
- Pirsall Robert Skott
- Kumar Ravindra
|
RU2642302C1 |
| COMBINED USE OF GDF TRAPS AND ERYTHROPOIETIN RECEPTOR ACTIVATORS TO INCREASE ERYTHROCYTE COUNT |
2020 |
- Seehra, Jasbir
- Pearsall, Robert, Scott
- Kumar, Ravindra
|
RU2814047C2 |
| GBO-ACTRIIB RECOMBINANT PROTEIN FOR INCREASING MUSCLE MASS IN FARM ANIMALS AND POULTRY |
2022 |
- Lyashchuk Aleksandr Mikhajlovich
- Lunin Vladimir Glebovich
- Lunin Afanasij Vladimirovich
|
RU2792817C1 |
| USE OF MYOSTATIN ANTAGONISTS, COMBINATION CONTAINING THEM AND THEIR USE |
2016 |
- Klickstein, Lloyd B.
- Roubenoff, Ronenn
- Feige, Jerome
- Trifilieff, Estelle
|
RU2781401C2 |
| NUETRALISING ANTIBODIES AGAINST GDF-8 AND THEIR APPLICATION |
2003 |
- Fel'Dman Gejtruida M.
- Dehvis Monik V.
- Song Kening
- Vol'Fman Nehjl M.
- Grouv-Bridzhes Kristi
- Fild Ehnn
- Rassell Kehrolajn
- Val'Ge-Arkher Fija
|
RU2360925C2 |
