CELECOXIB PRODRUG, METHOD FOR ITS PREPARATION AND USE Russian patent published in 2024 - IPC A61K31/635 A61K47/54 A61P27/02 A61P29/00 A61K9/08 

FIELD: chemistry; pharmaceutics.

SUBSTANCE: invention relates to a prodrug of celecoxib of formula I or a pharmaceutically acceptable salt thereof, a method for production thereof, medicinal agent or a pharmaceutical composition based thereon and use thereof for preparing a medicinal agent for preventing and/or treating inflammation of eye tissue. Also disclosed are eye drops for preventing and/or treating inflammation of eye tissue, containing the following components per 100 ml of eye drops: 0.1 g of a compound of formula I according to cl. 1 or 2, 0.05 g of Tween-80, 0.45 g of polyoxyethylene hydrogenated castor oil 40, 0.9 g of sodium chloride, 0.01 g of benzalkonium chloride, the rest is distilled water; wherein the pH value of the eye drops is 5.5–6.5.

EFFECT: use of the group of inventions makes it possible to effectively treat inflammations of eye tissue.

10 cl, 2 dwg, 4 tbl, 4 ex