FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel derivatives of indole of the formula (I): wherein R means ethyl or 2,2,2-trifluoroethyl group; Y means hydroxy- or pivaloylhydroxy-group and carbon atom labeled by symbol (R) is carbon atom in (R)-configuration, or its pharmaceutically acceptable salt. Compound of the formula (I) reduces intraocular pressure that allows its using in pharmaceutical composition eliciting blocking activity with regards to α-adrenoceptors and useful for prophylaxis or treatment of glaucoma also. EFFECT: valuable medicinal properties of compounds. 13 cl, 5 tbl, 13 ex
Title |
Year |
Author |
Number |
DERIVATIVES OF AMINOETHYLPHENOXYACETIC ACID AND MEDICINAL AGENTS FOR PAIN RELIEF AND STONE MOVING AWAY RELIEVE IN CHOLELITHIASIS |
1998 |
- Tamai Tetsuro
- Tanaka Nobujuki
- Muranaka Khidejuki
- Mukajjama Kharunobu
- Khirabajasi Akikhito
- Sato Masaaki
- Akakhane Masuo
|
RU2196130C2 |
INDOLINE COMPOUND AND METHOD OF PRODUCING SAID COMPOUND |
2005 |
- Jamaguti Tosiaki
- Tsutija Ikuo
- Kikuti Ken
- Janagi Takasi
|
RU2379289C2 |
PEPTIDE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF DISEASE TREATMENT INTERMEDIARY AGENT OF THAT IS TACHIKININ |
1991 |
- Masaaki Matsuo[Jp]
- Dajdziro Khagivara[Jp]
- Khirosi Mijake[Jp]
|
RU2073683C1 |
PYRAZOLE DERIVATIEVES, MEDICAL COMPOSITIONS, CONTAINING SAID DERIVATIVES, THEIR APPLICATION IN MEDICINE AND INTERMEDIATE COMPOUNDS FOR THEIR OBTAINING |
2003 |
- Teranisi Khirotaka
- Fusimi Nobukhiko
- Jonekubo Sigeru
- Simizu Kazuo
- Sibazaki Tosikhide
- Isadzi Masajuki
|
RU2356906C2 |
ANTIBIOTIC COMPOSITION |
1988 |
- Kazuo Sakane[Jp]
- Nobuesh Jasuda[Jp]
- Sintaro Nisimura[Jp]
|
RU2029549C1 |
AMIDES OF ACIDS, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
2000 |
|
RU2208608C2 |
DERIVATIVES OF PYRAZOLO-[1,5-A]-PYRIDINE OR THEIR PHARMACEUTICAL ACCEPTABLE SALTS AND METHOD OF THEIR SYNTHESIS |
1992 |
- Euiti Siokava[Jp]
- Atsusi Akakhane[Jp]
- Khirokhito Katajama[Jp]
- Takafumi Mitsunaga[Jp]
|
RU2069662C1 |
5-MEMBERED HETEROCYCLIC COMPOUND AND ITS APPLICATION FOR MEDICINAL PURPOSES |
2008 |
- Simizu Kazuo
- Takigava Jasusi
- Fudzikura Khideki
- Iizuka Masato
- Khiratoti Masakhiro
- Kikuti Norikhiko
|
RU2515968C2 |
NEW CATECHIN DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING CATECHIN DERIVATIVE, USING CATECHIN DERIVATIVE AND USING PHARMACEUTICAL COMPOSITION |
2008 |
- Isikava Takekhiro
- Inoue Khitosi
- Kobajasi Satoko
- Josida Masako
- Siokhara Khiroaki
- Ueno Jasunori
- Tanaka Nobujuki
|
RU2459812C2 |
DERIVATIVES OF AMINOMETHYLPYRROLIDINE WITH AROMATIC SUBSTITUTES |
2000 |
- Takemura Makoto
- Takakhasi Khisasi
- Kavakami Katsukhiro
- Takeda Tosijuki
- Mijauti Rie
|
RU2255938C2 |