NOVEL BENZOTRIAZOLE DERIVATIVE HAVING ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE INHIBITORY ACTIVITY, AND USE THEREOF Russian patent published in 2024 - IPC C07D249/18 C07D401/06 C07D401/04 C07D403/04 C07D409/04 A61K31/4192 A61K31/4439 A61K31/55 A61P35/00 

FIELD: pharmaceutics.

SUBSTANCE: present invention relates to benzotriazole derivatives, specifically to a compound of formula 1 or a pharmaceutically acceptable salt thereof, in which W₁ is C; W₂ is C; W₃ is C; W₄ is C; W₅ is N; W₆ is N; W₇ is N; where each of R₁, R₂, R₃ and R₄ independently represents hydrogen, hydroxyl group, halogen group, -CF₃, -(O)CF₃, C₁-C₆ alkyl group, C₁-C₆ alkoxy group or an amino group -NR₇R₈; Z is present or absent, wherein, when Z is present, Z is -CH₂ or -C₂H₄; R₅ is -A-R₆, where A is C₃-C₆ cycloalkyl, C₅ bicycloalkyl, C₄-C₆ heterocyclic group, containing one N heteroatom, optionally fused with phenyl, phenyl group or C₄-C₅ heteroaryl group containing one heteroatom, selected from a group consisting of N and S, R₆ is a carboxyl group (-C(O)OH), a nitrile group (-CN), -S(O)₂NHR₇, -CH₂NHS(O)₂NHR₇, CH(CH₃)NHS(O)₂NHR₇, -CH(CH₃)NHS(O)₂NH₂, -CH₂NHS(O)₂NH₂, CH₂NR₇S(O)₂NH₂, -S(O)₂NH₂, -C₂H₄NHS(O)₂NH₂, -CH₂NHS(O)₂R₇, CH₂NHSO(NH)R₇, -CH₂NHP(O)OR₇OR₈, or -CH₂NHP(O)(OH)₂, A can be further substituted with one or two substituents independently selected from the group consisting of a halogen group, a methyl group, a nitrile group (-CN) and a methoxy group, in addition to R₆, and each of R₇ and R₈ independently represents hydrogen, C₁-C₆ alkyl group, phenyl group substituted or unsubstituted with C₁-C₆ alkyl, amino group (-NH₂), -Boc, or -NHBoc. Invention also relates to a pharmaceutical composition, ENPP 1 inhibitor and a STING signaling pathway activator based on said compound.

EFFECT: design of alternative compounds for treating ENPP1-mediated diseases, as well as diseases mediated by the STING signaling pathway.

7 cl, 4 tbl, 124 ex