SUBSTITUTED PYRAZOLOPYRIMIDINES AND SUBSTITUTED PURINES AND USE THEREOF AS INHIBITORS OF UBIQUITIN-SPECIFIC PROCESSING PROTEASE 1 (USP1) Russian patent published in 2025 - IPC C07D487/04 A61K31/519 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, where X¹, X², X¹¹, X¹², R¹, R³, R⁵, R^5', R⁶ and R⁷ are defined in the claims as USP1 inhibitors. Also disclosed are pharmaceutical compositions containing compounds of formula I, and a method of inhibiting protein USP1.

EFFECT: compounds of formula I can be used to treat a disorder responsive to inhibition of USP1 proteins, particularly for treating cancer.

13 cl, 7 tbl, 224 ex