1,2,4-TRIAZOLE DERIVATIVE, METHODS FOR ITS PREPARING, PHARMACEUTICAL COMPOSITION, INTERMEDIATE COMPOUND AND METHOD FOR ITS PREPARING Russian patent published in 2006 - IPC C07D249/08 C07D213/60 C07D237/10 C07D401/04 C07D403/04 A61K31/4196 A61P29/00 

FIELD: organic chemistry, medicine.

SUBSTANCE: invention describes a novel triazole derivative of the general formula (I): wherein R₁ represents phenyl group optionally substituted with one or two groups chosen from (C₁-C₆)-alkyl group, (C₁-C₆)-halogenalkyl group, (C₁-C₆)-alkoxy-group, (C₁-C₆)-halogenalkoxy-group, halogen atom, nitro-group or cyano-group, styrenyl group, (C₁-C₆)-alkoxystyrenyl-group or pyridyl group; R₂ represents methyl or amino-group; A and B are carbon atoms; C and D represent independently carbon or nitrogen atom, and its nontoxic salt and pharmaceutical composition based on thereof. Also, invention relates to methods for synthesis of novel compounds, novel intermediate substances of the formula: wherein R₂, A, B, C and D have above given values; n means a whole number from 0 to 2, and to a method for their synthesis. Compounds of the formula (I) possess anti-inflammatory activity and can be used potentially in treatment of fever, pain and inflammation.

EFFECT: improved method of synthesis, valuable medicinal properties of compounds and pharmaceutical composition.

9 cl, 2 tbl, 50 ex