FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to the use of an Fc-fusion protein for treating cancer, wherein said Fc-fusion protein is a homodimer of two polypeptides, each of which contains (i) an IgG immunoglobulin Fc domain and (ii) a heterologous polypeptide comprising the human IL-10 sequence from SEQ ID NO: 1 or a variant thereof, wherein the heterologous polypeptide is covalently bonded to the N-terminus of the Fc domain via a polypeptide linker, and two heterologous polypeptides are non-covalently bonded into a homodimer. Also disclosed is a pharmaceutical composition for treating cancer. Invention also relates to a method for preventing or treating cancer, a method for stimulating immunity in a subject and a method for restoring the ability to respond to immunotherapy in a subject.
EFFECT: invention provides the use of the IL-10 / Fc fusion protein as an immunotherapy enhancer.
31 cl, 7 dwg, 1 tbl, 4 ex
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Year |
Author |
Number |
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2020 |
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2019 |
|
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|
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2016 |
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|
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| HETERODIMERIC FUSED PROTEINS IL-15/IL-15Pα-Fc AND USE THEREOF |
2019 |
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|
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2021 |
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|
RU2831612C1 |
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|
RU2818371C1 |
| NOVEL FUSION PROTEIN SPECIFIC FOR CD137 AND PD-L1 |
2019 |
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|
RU2818349C2 |
