LONG-ACTING ADRENOMEDULLINE DERIVATIVE Russian patent published in 2024 - IPC C07K14/575 A61K38/22 A61K47/60 A61P29/00 A61P9/00 

FIELD: biotechnology; medicine.

SUBSTANCE: group of inventions relates to a novel adrenomedulline derivative, a method for production and use thereof. Disclosed is a compound which increases intracellular concentration of cAMP, represented by formula: A'-CO-B (X), where A' represents a modifying group containing one or more polyethylene glycol groups with weight average molecular weight from 1 to 100 kDa, and B represents a peptide fragment obtained from adrenomedulline or its modified form with adrenomedullin activity. Peptide fragment B is bonded to -CO through a covalent bond between the nitrogen atom of the N-terminal α-amino group of peptide fragment B and carbon atom of carbonyl group. Said compound or its pharmaceutically acceptable salt or hydrate are suitable for preventing or treating cardiovascular disease, inflammatory disease or peripheral vascular disease.

EFFECT: inventions provide a significant increase in the intracellular concentration of cAMP, prolong the blood half-life of the adrenomedulline derivative, significantly suppress undesirable side reactions while maintaining pharmacological effects of adrenomedulline.

13 cl, 21 dwg, 5 tbl, 62 ex