PHARMACEUTICAL COMPOSITION CONTAINING THROMBOLYTIC PEPTIDE-TETRAHYDROISOQUINOLINE CONJUGATE Russian patent published in 2024 - IPC A61K31/4725 A61K38/06 A61K47/26 A61K47/55 A61K9/19 

FIELD: medicine; pharmaceutics.

SUBSTANCE: object 1 is a pharmaceutical composition containing (a) a compound of formula , or a pharmaceutically acceptable salt thereof, and (b) a pharmaceutically acceptable excipient, where the pharmaceutically acceptable excipient is mannitol, sorbitol, sucrose, lactose or trehalose, where the composition has a pH value equal to approximately pH 2 - pH 5.5 and the weight ratio of the compound and the pharmaceutically acceptable excipient is approximately from 1:1 to 1:9. Object 2 is lyophilized pharmaceutical composition containing (a) said compound or its pharmaceutically acceptable salt and (b) mannitol, wherein the weight ratio of the compound to mannitol is from about 1:1.3 to 1:3.8, and the pH of the pharmaceutical composition has a value of about 4.5 after reconstitution with normal saline to concentration of 10 to 20 mg/ml.

EFFECT: stability of the pharmaceutical composition.

14 cl, 1 dwg, 12 tbl, 6 ex