FORMULATIONS WITH ADENO-ASSOCIATED VIRUS Russian patent published in 2022 - IPC A61K35/76 A61K47/26 A61K47/18 A61K47/02 A61P7/00 

FIELD: medicine; pharmaceutics.

SUBSTANCE: present document provides liquid and lyophilised pharmaceutical compositions with adeno-associated virus. According to illustrative aspects, pharmaceutical compositions contain from about 5 mM to about 25 mM L-histidine, from about 0 mM to about 150 mM sodium chloride, from approximately 0.001 % (weight/volume) to approximately 0.01 % (weight/volume) of polysorbate 80 (PS80) and from approximately 1 % to approximately 10 % (weight/volume) of sucrose, trehalose or their combination with AAV. According to illustrative aspects, the pharmaceutical compositions additionally contain glycine or mannitol.

EFFECT: there are presented methods for preparing a pharmaceutical composition containing AAV, methods for treating a blood coagulation disorder in a subject and methods for storing compositions with AAV.

53 cl, 70 tbl, 8 ex