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C2

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IPC

C07D403/04(2006-01-01)

C07D403/14(2006-01-01)

C07D413/04(2006-01-01)

C07D413/14(2006-01-01)

C07D401/04(2006-01-01)

C07D401/14(2006-01-01)

C07D405/04(2006-01-01)

C07D405/14(2006-01-01)

C07D409/04(2006-01-01)

C07D417/04(2006-01-01)

C07D471/04(2006-01-01)

C07D487/04(2006-01-01)

C07D513/04(2006-01-01)

A61K31/4192(2006-01-01)

A61K31/416(2006-01-01)

A61K31/429(2006-01-01)

A61K31/437(2006-01-01)

A61K31/4985(2006-01-01)

A61K31/4178(2006-01-01)

A61K31/519(2006-01-01)

A61K31/427(2006-01-01)

A61K31/422(2006-01-01)

A61K31/454(2006-01-01)

A61K31/5377(2006-01-01)

A61P25/28(2006-01-01)

A61P3/10(2006-01-01)

A61P25/18(2006-01-01)

A61P35/00(2006-01-01)

A61P11/06(2006-01-01)

A61P15/00(2006-01-01)

A61P13/12(2006-01-01)

A61P9/10(2006-01-01)

A61P31/04(2006-01-01)

A61P43/00(2006-01-01)

(21) (22)

Application

2009149696/04, 2008-06-04

(24)

Start date

2008-06-04

(22)

Actual filing date

2008-06-04

(45)

Published

2013-07-20

(72)

Inventor

Akritopoulou-Zanze IriniUehjkfild Brajan D.Mak Khel'MutTerner Shon K.Gasiki Alan F.Grasias Vidzhaja Dzh.Sarris KehtiKalvin Duglas M.Michmerkhuzen Melissa Dzh.Shuaj TsiPatel Dzhioti R.Bakker MargaretaTojsh Nikol'Dzhonson Ehrik F.Kovar Piter Dzh.D'Jurik Stiven V.Long Ehndrju Dzh.Vasudevan AnilKhobson AdrianSt. Dzhon Mur NajdzhelVan LuDzhorzh DonLi Bitsin'Frank Kristin

(73)

Holder

Ehbbott LehboretrizEhbbott Gmbkh Und Ko. Kg

5-SUBSTITUTED INDAZOLE AS KINASE INHIBITORS Russian patent published in 2013 - IPC C07D403/04 C07D403/14 C07D413/04 C07D413/14 C07D401/04 C07D401/14 C07D405/04 C07D405/14 C07D409/04 C07D417/04 C07D471/04 C07D487/04 C07D513/04 A61K31/4192 A61K31/416 A61K31/429 A61K31/437 A61K31/4985 A61K31/4178 A61K31/519 A61K31/427 A61K31/422 A61K31/454 A61K31/5377 A61P25/28 A61P3/10 A61P25/18 A61P35/00 A61P11/06 A61P15/00 A61P13/12 A61P9/10 A61P31/04 A61P43/00 

Abstract RU 2487873 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to compounds of formula (I) or pharmaceutically acceptable salts thereof wherein A, R1, R2, R3 and m are specified in the patent claim. The present invention also refers to the number of specific compounds, and to a pharmaceutical composition containing the above compounds effective for inhibition of kinases, such as glycogen synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus kinase (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.

EFFECT: preparing the specific compounds and pharmaceutical composition containing the above compounds effective for kinase inhibition.

18 cl, 393 ex

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RU 2 487 873 C2

Authors

Akritopoulou-Zanze Irini

Uehjkfild Brajan D.

Mak Khel'Mut

Terner Shon K.

Gasiki Alan F.

Grasias Vidzhaja Dzh.

Sarris Kehti

Kalvin Duglas M.

Michmerkhuzen Melissa Dzh.

Shuaj Tsi

Patel Dzhioti R.

Bakker Margareta

Tojsh Nikol'

Dzhonson Ehrik F.

Kovar Piter Dzh.

D'Jurik Stiven V.

Long Ehndrju Dzh.

Vasudevan Anil

Khobson Adrian

St. Dzhon Mur Najdzhel

Van Lu

Dzhorzh Don

Li Bitsin'

Frank Kristin

Dates

2013-07-20—Published

2008-06-04—Filed

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