FIELD: medicine; pharmaceutics.
SUBSTANCE: invention relates to medicine, pharmacology and chemical-pharmaceutical industry, specifically to an improved method of producing (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide of sodium. Method involves reaction of (4R,12aS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide with lithium bromide in the presence of citric acid or its hydrate, followed by addition of sodium hydroxide.
EFFECT: invention increases output and purity of the end product.
11 cl, 5 tbl, 1 ex
| Title |
Year |
Author |
Number |
| METHOD OF PRODUCING SODIUM (4R,12aS)-N-(2,4-DIFLUOROBENZYL)-7-HYDROXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12a-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE |
2024 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
RU2828089C1 |
| METHOD OF PURIFYING COMPOUND (4R,12aS)-N-(2,4-DIFLUOROBENZYL)-7-METHOXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12a-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE |
2024 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
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| METHOD OF PURIFYING SODIUM (4R,12aS)-N-(2,4-DIFLUOROBENZYL)-7-HYDROXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12a-HEXAHYDRO-2H-PYRIDO-[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE |
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- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
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|
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