FIELD: medicine; pharmaceutics.
SUBSTANCE: invention relates to medicine, pharmacology and chemical-pharmaceutical industry, specifically to an improved method of producing (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide of sodium. Method involves reaction of (4R,12aS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide with lithium bromide in the presence of citric acid or its hydrate, followed by addition of sodium hydroxide.
EFFECT: invention increases output and purity of the end product.
11 cl, 5 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
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