FIELD: medicine; pharmaceutics.
SUBSTANCE: invention relates to medicine, pharmacology and chemical-pharmaceutical industry, specifically to an improved method of producing (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide of sodium (compounds of formula (II)). Method involves reaction of (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide with sodium hydroxide in a mixture of solvents consisting of methylene chloride and alcohol in volume ratios of 1.00:2.00–1.00:10.00, respectively.
EFFECT: invention increases output and purity of the end product.
6 cl, 5 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING SODIUM SALT OF (4R,12AS)-N-(2,4-DIFLUOROBENZYL)-7-HYDROXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12A-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE | 2024 |
|
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