FIELD: medicine.
SUBSTANCE: invention relates to medicine, pharmacology and chemical-pharmaceutical industry, specifically to a novel improved method of purifying compound (4R,12aS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide (compound of formula (III)). Method is carried out by recrystallisation of a compound of formula (III) from a mixture of solvents consisting of tert-butyl methyl ether and one of two: isopropyl acetate or isobutanol, where the weight ratio of tert-butyl methyl ether to isopropyl acetate or isobutanol ranges from 2.00:1.00 to 80.00:1.00, respectively.
EFFECT: disclosed method enables to achieve high output and purity of the end product.
5 cl, 5 tbl, 1 ex
| Title |
Year |
Author |
Number |
| METHOD OF PRODUCING SODIUM (4R,12aS)-N-(2,4-DIFLUOROBENZYL)-7-HYDROXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12a-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE |
2024 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
RU2828089C1 |
| METHOD OF PRODUCING SODIUM SALT OF (4R,12AS)-N-(2,4-DIFLUOROBENZYL)-7-HYDROXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12A-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE |
2024 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
RU2826745C1 |
| METHOD OF PURIFYING SODIUM (4R,12aS)-N-(2,4-DIFLUOROBENZYL)-7-HYDROXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12a-HEXAHYDRO-2H-PYRIDO-[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE |
2024 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
RU2828087C1 |
| METHOD OF PURIFYING (4R,12aS)-N-(2,4-DIFLUOROBENZYL)-7-HYDROXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12a-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE |
2024 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
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| METHOD OF PURIFYING (4R,12AS)-N-(2,4-DIFLUOROBENZYL)-7-HYDROXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12A-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE OF SODIUM |
2024 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
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2024 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
RU2828097C1 |
| METHOD OF PURIFYING COMPOUND (4R,12aS)-N-(2,4-DIFLUOROBENZYL)-7-METHOXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12a-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE |
2024 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
RU2828094C1 |
| METHOD OF PRODUCING (4R,12AS)-N-(2,4-DIFLUOROBENZYL)-7-HYDROXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12A-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE OF SODIUM |
2024 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
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| ANELLATED 9-HYDROXY-1,8-DIOXO-1,3,4,8-TETRAHYDRO-2H-PYRIDO[1,2-A]PYRAZINE-7-CARBOXAMIDES - INTEGRASE INHIBITORS, METHODS FOR PREPARING AND USING THEREOF |
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|
RU2717101C1 |
| NEW AZABICYCLOHEXANE DERIVATIVES |
2023 |
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