METHOD FOR CORRECTING COMPLEX OF METABOLIC AND HORMONAL PARAMETERS IN TYPE 2 DIABETES MELLITUS USING INTRANASALLY ADMINISTERED INSULIN Russian patent published in 2024 - IPC A61K38/28 A61P3/10 

FIELD: medicine; endocrinology.

SUBSTANCE: invention can be used to correct a complex of metabolic and hormonal parameters in type 2 diabetes mellitus with the help of intranasal insulin. Course application of intranasally administered insulin is carried out for 6 weeks in the dose range of 3 to 15 IU/kg/day. Complex of metabolic and hormonal indicators includes nine metabolic indicators—fat tissue mass, basic glucose level, glucose level 120 minutes after glucose load, glycated hemoglobin, AUC0-120 value for the glucose curve, total cholesterol, triglycerides, high-density lipoproteins, atherogenicity index, as well as fifteen hormonal indicators—baseline concentrations of insulin and leptin, glucose-stimulated concentrations of insulin and leptin, insulin resistance index, glucose-stimulated concentration of glucagon-like peptide-1, concentration ratio of leptin/adiponectin and leptin/ghrelin, free thyroxine, free and total triiodothyronine, total testosterone, ratios of concentrations of triiodothyronine/thyrotropic hormone, testosterone/luteinizing hormone and testosterone/estradiol.

EFFECT: method provides the complex restoration of metabolic and hormonal parameters disturbed in type 2 diabetes mellitus and affecting the severity, pathogenesis and prognosis of the disease, in the absence of risks of developing life-threatening hypoglycemic episodes due to the use of intranasal insulin supplied directly to brain structures, bypassing the blood-brain barrier.

1 cl, 6 dwg