PHARMACEUTICAL COMPOSITION CONTAINING PYRIDINE COMPOUND AND USE THEREOF IN ROS1-POSITIVE NON-SMALL CELL LUNG CANCER Russian patent published in 2024 - IPC A61K31/4545 A61P35/00 C07D401/14 

Abstract RU 2827402 C2

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, in particular to a pharmaceutical composition containing a pyridine compound of formula (I), a method for preparing and using it. Disclosed pharmaceutical composition contains a compound of formula (I) or a pharmaceutically acceptable salt thereof, filler, lubricant and baking powder, where water content in filler is not more than 1.5 wt.%

wherein the filler is selected from one or from a mixture of microcrystalline cellulose and anhydrous calcium hydrophosphate, the baking powder is selected from one or a mixture of crospovidone and croscarmellose sodium, the lubricant is selected from one or a mixture of silicon dioxide and hydrogenated castor oil. Disclosed is an embodiment of the composition, which contains a compound of formula (I) or a pharmaceutically acceptable salt thereof, microcrystalline cellulose, anhydrous calcium phosphate, croscarmellose sodium, silicon dioxide and hydrogenated castor oil, in which content of water in microcrystalline cellulose and anhydrous calcium hydrophosphate is not more than 1.5 wt.%. Method for preparing the above pharmaceutical composition involves: a) grinding a compound of formula (I) or a pharmaceutically acceptable salt thereof; b) mixing a compound of formula (I) or a pharmaceutically acceptable salt thereof, obtained at step (a), with a filler, a disintegrant and part of a lubricant and sieving the mixture and c) mixing the mixture with the remaining lubricant. Also disclosed is use of said composition in preparing a drug for preventing or treating non-small cell lung cancer, particularly ROS1-positive non-small cell lung cancer.

EFFECT: pharmaceutical composition has good stability and fluidity and is suitable for industrial production of a medicinal agent for clinical use.

15 cl, 2 dwg, 2 tbl, 4 ex

Similar patents RU2827402C2

Title Year Author Number
MEDICAL USE OF PYRROLOPYRIMIDINE COMPOUND AND SOLID PHARMACEUTICAL COMPOSITION OF PYRROLOPYRIMIDINE COMPOUND 2019
  • Wang Dong
  • Li Qingxia
  • Dai Jun
  • Li Chen
  • Jiang Zhulian
  • Sun Yanqing
  • Chen Jingjing
  • Jin Lingling
  • Liu Jundong
  • Li Qide
RU2810112C2
SOLID PHARMACEUTICAL COMPOSITION CONTAINING TLR7 AGONIST 2020
  • Jing, Jianghui
  • Dong, Lihui
  • Xu, Yi
  • Li, Xinlu
  • Lu, Xifeng
  • Wang, Shang
  • Zang, Haishan
  • Li, Min
  • Chen, Zhilin
  • Zhao, Xiandong
  • Sun, Peng
RU2822480C2
PHARMACEUTICAL COMPOSITION CONTAINING PARP INHIBITORS 2019
  • Xu, Jiajia
  • Chen, Hao
  • Wang, Xu
RU2785677C1
DRY GRANULATION PROCESS FOR PRODUCING TABLET COMPOSITIONS OF METFORMIN AND COMPOSITIONS THEREOF 2013
  • Ashkhar Gezde
  • Oran Umut
  • Bitik Nadzhi
  • Adyyaman Mustafa
RU2647421C2
PHARMACEUTICAL COMPOSITION CONTAINING A PYRROLE-CONDENSED SIX-MEMBERED HETEROCYCLIC COMPOUND 2017
  • Lu, Yun
  • Zhang, Xinhua
  • Wang, Chenyang
  • Liu, Tonghui
RU2737734C2
SOLID DOSAGE FORMS OF PALLBOCYCLOB 2016
  • Ibrahim Fady Makram Louiz
  • Mullarney Matthew Patrick
  • Shanker Ravi Mysore
  • Spong Barbara Rodriguez
  • Wang Jian
RU2686840C1
STABLE PHARMACEUTICAL COMPOSITION OF WATER-SOLUBLE SALT OF VINORELBINE 2008
  • Pejjar Bruno
  • Avan Zhan-Lui
  • Bugare Zhoehl'
RU2476208C2
STABLE PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION COMPRISING LEVOCETIRIZINE, OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND MONTELUKAST OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF 2013
  • Kvon Taek Kvan
  • Kim Dong Kho
  • Kim Kieong Soo
  • Kim Jong Il
  • Park Dzae Khiun
  • Voo Dzong Soo
RU2614382C2
PHARMACEUTICAL COMBINATION, COMPOSITION, AND COMBINED COMPOSITION, CONTAINING GLUCOKINASE ACTIVATOR AND PPAR RECEPTOR ACTIVATOR, AND THEIR PREPARATION METHOD, AND THEIR USE 2019
  • Chen, Li
  • Li, Yongguo
  • Wang, Gaosen
  • Gao, Huisheng
RU2781638C2
PHARMACEUTICAL COMBINATION, COMPOSITION, AND COMBINED COMPOSITION CONTAINING GLUCOKINASE ACTIVATOR AND BIGUANIDE HYPOGLYCEMIC DRUG, AS WELL AS THEIR PREPARATION METHOD, AND THEIR USE 2019
  • Chen, Li
  • Li, Yongguo
  • Wang, Gaosen
RU2780377C2

RU 2 827 402 C2

Authors

Lu Xifeng

Dong Lihui

Zhou Hao

Li Xinlu

He Xiongxiong

Jiang Bo

Zhao Xiandong

Dong Ping

Zhao Zekai

Wang Hongyun

Yang Tie

Jia Jiaojiao

Chen Jie

Zhang Xiquan

Wang Xunqiang

Su Nan

Dates

2024-09-25Published

2020-05-22Filed