FIELD: medicine.
SUBSTANCE: group of inventions relates to solid dosage forms of pallbocyclib. Solid dosage form of pallbocyclib in the form of tablet contains 10 to 35 wt. % palbocyclib, 5 to 25 wt. % water-soluble acid selected from a group consisting of succinic acid, malic acid and tartaric acid, and a pharmaceutically acceptable carrier. In particular, tablet contains 20 wt. % palbocyclib, 10 wt. % succinic acid, 50 to 63 wt. % microcrystalline cellulose, 5 to 10 wt. % crospovidone and 0.5 to 6 wt. % magnesium stearate.
EFFECT: group of inventions provides stability during storage of solid dosage form of palbocyclib and its delivery, not depending on pH, without significant effect of food intake or undesirable interactions with proton pump inhibitors.
14 cl, 4 dwg, 23 tbl, 21 ex
