NOVEL ANTHELMINTIC COMPOUNDS Russian patent published in 2024 - IPC C07D241/42 C07D249/18 C07D311/58 C07D311/68 C07D405/12 C07D405/14 C07D407/12 C07D409/12 C07D471/04 C07D495/04 A61K31/352 A61K31/353 A61K31/37 A61K31/381 A61K31/4192 A61K31/4365 A61K31/437 A61K31/4375 A61K31/472 A61K31/498 A61K31/5377 A61P33/10 

FIELD: chemistry; pharmaceutics.

SUBSTANCE: invention relates to a compound of general formula (I), stereoisomers thereof, pharmaceutically acceptable salts, as well as mixtures thereof. In formula (I) A is A1 or A2, o is 0 or 1; R is selected from the group consisting of hydrogen, halogen, C₁-C₄-alkyl and C₁-C₄-halogenalkyl having from 1 to 5 halogen atoms; X is selected from a group consisting of CR⁷R⁸, O, S and N-R⁹, Y represents CR⁷R⁸; T selected from T¹, T², T³, T⁴, T⁵, T⁶, T⁷, T^8a, T^8b and T⁹; U is selected from a group consisting of CR⁷ and N; V is selected from a group consisting of CR⁷ and N; L is selected from a group consisting of O and NR⁹; M is selected from a group consisting of C = O and NR⁷R⁸; R¹ is selected from the group consisting of hydrogen and C₁-C₄-alkyl; R² is selected from a group consisting of hydrogen, halogen, -NR¹²R¹³, -OR¹⁴, -SR¹⁵, C₁-C₆-alkyl, which is optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, cyano and C₁-C₄-alkyl, monocyclic heterocycle, 5-membered heteroaryl and 6-membered heteroaryl; R³ is selected from the group consisting of hydrogen, halogen or C₁-C₄-alkyl; R⁴ is selected from the group consisting of hydrogen, halogen, C₁-C₄-alkyl, C₁-C₄-halogenalkyl, having from 1 to 5 halogen atoms; R⁵ is selected from the group consisting of hydrogen, halogen, C₁-C₄-alkyl, C₁-C₄-halogenalkyl, having from 1 to 5 halogen atoms; R⁶ is selected from the group consisting of hydrogen, halogen, C₁-C₄-alkyl, C₁-C₄-halogenalkyl, having from 1 to 5 halogen atoms; R⁷ is selected from the group consisting of hydrogen, halogen, C₁-C₄-alkyl; R⁸ is selected from the group consisting of hydrogen, halogen, C₁-C₄-alkyl; R⁹ is selected from the group consisting of hydrogen, C₁-C₄-alkyl; R¹⁰ is selected from the group consisting of hydrogen, C₁-C₄-alkyl; R¹¹ is selected from a group consisting of hydrogen; R¹² and R¹³ are independently selected from the group consisting of hydrogen and C₁-C₄-alkyl, which is optionally substituted with 1, 2 or 3 substitutes independently selected from the group consisting of halogen, -OH, cyano, C₁-C₄-alkyl and C₁-C₄-halogenalkyl, having from 1 to 5 halogen atoms, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy having from 1 to 5 halogen atoms; R¹⁴ is C₁-C₄-alkyl, which is optionally substituted with 1, 2 or 3 substitutes independently selected from the group consisting of halogen, C₁-C₄-alkyl and C₁-C₄-halogenalkyl, having from 1 up to 5 halogen atoms; R¹⁵ is C₁-C₄-alkyl, which is optionally substituted with 1, 2 or 3 substitutes independently selected from the group consisting of halogen, C₁-C₄-alkyl and C₁-C₄-halogenalkyl, having from 1 up to 5 halogen atoms; R¹⁶ is selected from the group consisting of hydrogen, C₁-C₄-alkyl and C₁-C₄-halogenalkyl having from 1 to 5 halogen atoms; R¹⁷ is selected from the group consisting of hydrogen, C₁-C₄-alkyl and C₁-C₄-halogenalkyl, having from 1 to 5 halogen atoms; Q is selected from the group consisting of 6-membered aryl and 5–6-membered heteroaryl substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of halogen, C₁-C₄-alkyl and C₁-C₄-halogenalkyl having from 1 to 5 halogen atoms. Invention also relates to a method of producing said compounds, a pharmaceutical composition containing said compounds and a method of controlling infections caused by helminths using said compounds.

EFFECT: compounds can be used for control, treatment and / or prevention of infection caused by helminths.

11 cl, 3 tbl, 56 ex