NEW QUINOLINE DERIVATIVES Russian patent published in 2023 - IPC C07D405/14 C07D215/54 C07D215/56 C07D405/12 A61K31/47 A61P33/10 

FIELD: organic chemistry.

SUBSTANCE: group of inventions namely relates to quinoline derivatives of the general formula (I) as anthelmintic agents. Disclosed is a compound with general formula (I), where: A is A1 or A2, o is 0, 1 or 2, R is selected from the group consisting of halogen, C₁-C₄ alkyl, C₁-C₄ alkoxy and cyano, R_p is selected from the group consisting of from hydrogen, X is selected from the group consisting of CR⁷ R⁸, O and S, Y is CR⁷R⁸ or O, R¹ is hydrogen or C₁-C₄ alkyl, R² is selected from the group consisting of from tetrahydro-2H-pyran-4-yl, 3,6 dihydro-2H-pyran-4-yl, ethyl and 3-fluoroazetidin-1-yl, R³ is hydrogen, R⁴ is selected from the group consisting of hydrogen, halogen, -OH, cyano, C₁-C₄-alkyl, C₁-C₄-haloalkyl having from 1 to 5 halogen atoms, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, having from 1 up to 5 halogen atoms, preferably hydrogen, halogen and C₁ -C₄ -alkoxy, more preferably fluorine, chlorine, methoxy and isopropoxy, R⁵ is selected from the group consisting of hydrogen, R⁶ is selected from the group consisting of hydrogen, R⁷ selected from the group consisting of hydrogen and C₁-C₄-alkyl, R⁸ selected from the group consisting of hydrogen and C₁-C₄-alkyl, R¹⁰ is selected from the group consisting of hydrogen, R¹¹ is hydrogen, Q is 2,3,5-trifluorophenyl, or its stereoisomer, tautomer, or pharmaceutically or veterinarily acceptable salt, or mixture thereof Also disclosed is a process for preparing a compound with general formula (I), an intermediate compound with general formula (II), where the values of the radicals have the meanings indicated in the claims; a pharmaceutical composition based on a compound with formula (I); the use of a compound with formula (I); and a process for controlling helminth infections in humans and/or animals.

EFFECT: group of inventions provides effective treatment and control of helminth infections in humans and/or animals.

13 cl, 10 tbl, 7 ex