CRYSTALLINE FORM OF ATR INHIBITOR AND USE THEREOF Russian patent published in 2024 - IPC C07D471/04 A61K31/437 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to crystalline form B of a compound of formula (I), where crystalline form B has a powder X-ray diffraction pattern having characteristic diffraction peaks at following angles 2θ: 8.45 ± 0.20°, 10.87 ± 0.20°, 14.83 ± 0.20°, 15.54 ± 0.20° and 20.56 ± 0.20°. Method of producing crystalline form B of the compound of formula (I) according to the invention is carried out by (1) adding a compound of formula (I) to an alcohol solvent, (2) adding water, (3) stirring for 15–20 hours, (4) performing recrystallisation at room temperature to obtain crystalline form B, where the alcohol solvent is methanol; volume ratio of the alcohol solvent to water is 1:1–1:4, the concentration range of the compound of formula (I) is selected from a group consisting of 25–50 mg/ml. Invention also relates to use of the crystalline form B of the compound of formula (I) according to the invention for preparing a drug for treating a disease associated with ATR. (I).

EFFECT: crystalline form B of the compound of formula I, having stability, less susceptibility to light, heat and moisture, good drug efficacy in vivo and suitable for use as a drug.

13 cl, 4 dwg, 14 tbl, 13 ex